Glossary of Terms Used in Combinatorial
Chemistry
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[C] [D] [E-G]
[H-K] [L]
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L
Ladder Synthesis: Strategy for
library assembly where a portion of compound is capped following incorporation
of each building block such that the final sample comprises a mixture
of all possible truncated products. This may be designed such that approximately
equimolar quantities of each truncated form are present as an approach
to gain maximal diversity, or such that each truncate is present in
small amount relative to the fully elaborated product. In the latter
case analysis of the pattern of products serves to identify the parent
and is termed ladder encoding 55.
Libraries from Libraries: Strategy
for accelerating library production whereby an existing library is subjected
to a relatively minor modification in order to generate a new library,
thus avoiding the majority of chemical development and rehearsal
required for a new library 56.
Library: See Combinatorial
Library
Library Equivalent: The number
of samples which equals the number of compounds in the library. Particularly
applied to libraries in which individual beads are encoded,
where one library equivalent is the number of beads
which equals the number of compounds in the library. See also assay
equivalent.
Linker: Bifunctional chemical moiety attaching
compound to solid support
or soluble support which
can be cleaved to release compounds
from the support. Careful choice of linker allows cleavage to be performed
under appropriate conditions compatible with the stability of the compound
and assay method 57.
Lipinski’s Rules: see Rules
of Five
Liquid Phase Chemistry:
Synthetic process employing a macromolecular soluble
support 58,59.
Loading: Characteristic property of a
solid support which describes the amount of a specific chemical species
per unit mass of the support; see also Capacity.
