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Pure Appl. Chem.,
Vol. 71, No. 12, pp. 2349-2365, 1999
Glossary of Terms Used in Combinatorial
Chemistry
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T
Tag: (a) One of a set of surrogate analytes
which are used in a decoding process;
(b) pendant function which allows a molecule to be selected from a mixture
(see phase switch) 21,99.
Tea-Bag: A type of reaction vessel
consisting of a porous mesh which encloses the resin
but allows passage of reagents and solvents when immersed in an appropriate
secondary container. Several tea-bags may be treated in a single vessel
without mixing of the enclosed resins; manipulation of multiple tea-bags
allows preparation of libraries by pool/split
or directed sorting techniques 105.
Template: see Scaffold
TentaGel: (Trademark of Rapp Polymere
GmbH, Tubingen, Germany) Beaded solid support
with a crosslinked polystyrene
core and grafted linear poly(ethylene
glycol) (PEG) chains with terminal functional groups 106,107.
Tether: see Linker
Thematic Library: see Directed
Library
Tiered Release: see Partial
Release
Traceless Linker: Type of linker
which leaves no residue on the compound after cleavage,
i.e. is replaced by hydrogen, as in the acid-cleavable germanium-based
linker below 108-110.
> Introduction
> Notes
> References
> Alphabetical
Entries
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