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Pure Appl. Chem., Vol. 70, No. 11,
pp. 2137, 1998
Synthesis of (-)-trichoviridin*
Douglas F. Taber and Han Yu
Dept. of Chemistry and Biochemistry, U. of Delaware, Newark, DE 19716
USA
E-mail: [email protected]
Abstract: Trichoviridin 3 is representative of a small
family of isonitrile antibiotics having compact but highly functionalized
(and highly reactive) cyclopentane rings. The current rapid rise in
bacterial infections that do not respond to antibiotic therapy makes
it urgent that we pursue leads such as these. We will describe the first
asymmetric synthesis of 3, based on intramolecular alkylidene
carbene cyclization of the enantiomerically-pure ketone 1.
* Invited lecture presented at the International
Conference on Bioversity and Bioresources: Conservation and Utilization,
23-37 November 1997, Phuket, Thailand.
Page last modified 14 April 1999.
Copyright ©1997, 98, 99 International Union of Pure and Applied
Chemistry.
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