International Union of Pure and Applied Chemistry

Combinatorial libraries for studying molecular recognition*

Gordon Lowe, Susanna Leon and Rachel Quarell

Dyson Perrins Laboratory, Oxford University, South Parks Road, Oxford, OX1 3QY, UK
E-mail: [email protected]

Abstract: Combinatorial Libraries have great potential for studying biomolecular recognition. They consist of large numbers of structurally diverse compounds which can be generated rapidly. The key to their use is in the development of selection assays which allow the most active compounds to be identified. The most commonly used selection procedures are based on binding, the compound(s) with the highest affinity being isolated and identified. In this report some fundamental questions concerning the assaying of libraries on solid supports by enzyme catalysis are addressed.

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