International Union of Pure and Applied Chemistry

Novel antifungal compounds derived from heterocyclic positional scanning combinatorial libraries*

Sylvie E. Blondelle, Adel Nefzi, John M. Ostresh and Richard A. Houghten

Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA.
E-mail: [email protected]

Abstract: Synthetic combinatorial libraries composed of mixtures of tens thousands to millions of compounds have been shown to be useful in a wide range of biomedical research areas. The "libraries from libraries" concept was extended to the generation of heterocyclic synthetic combinatorial libraries from existing N-acylated dipeptide libraries. In particular, N-alkyl aminocyclic urea and thiourea SCLs were generated and assayed for their ability to inhibit Candida albicans growth. Potent individual anticandidal compounds were derived from these libraries.

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