||I U P A C
Organizations & People
Pure Appl. Chem.,
Vol. 68, No.12, pp. 2325-2332, 1996
ON MEDICINAL CHEMISTRY
utilization of natural biodiversity in context of search for economically
valuable medicinal biota
Prepared for publication by P.
R. Andrews (Australia), R. Borris (USA), E. Dagne (Ethiopia), M. P.
Gupta (Panama), L. A. Mitscher (USA), A. Monge
(Spain), N. J. De Souza (India) and J. G. Topliss (USA)
World Wide Web Version
text - pdf 581 kB]
Abstract: Natural products remain excellent
sources of leads in the search for novel medicaments for the treatment
of diseases. The largest present underexplored source of such materials
lies in tropical and subtropical regions. In these areas a long tradition
of ethnobotanical medicine often exists with which to guide laboratory
experimentation, but the finds, equipment and necessary expertise is
often lacking. The divergence between availability and the means with
which to develop provides the basis for significant disagreements over
the value to be placed on each party's contribution and represents a
factor which inhibits the development of these materials for mankind's
benefit. Various scientific societies, governmental agencies, industries,
groups and individuals have advanced their views, but confounding features
have prevented the emergence of an amicable consensus. The rapid rate
with which biota are disappearing has increased the urgency of the need
to find solutions to the problems which remain. IUPAC has considered
a number of declarations on the subject, particularly the Manila Declaration
of 1992 and the Melaka Accord of 1994, which are reproduced in an appendix,
and has made several recommendations it believes should be considered
by participants when promulgating declarations and enacting legislation
on the topic. This position paper sets forth IUPAC's views -on the subject
for the guidance of its members and affiliated organizations and is
not itself a declaration nor does it adopt by reference any particular
> See also General Features
of Contracts for Natural Product Collaborations
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