Application of toxicogenomics to the endocrine disruption issue
T. Shirai and M. Asamoto
Department of Experimental Pathology and Tumor Biology,
Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi,
Nagoya 467-8601, Japan
Abstract: Toxicogenomics can be expected to be a useful method
for detecting the carcinogenic potential of endocrine active substances
(EASs) in the short term with the generation of understanding of mode-of-action
and mechanisms when a reliable database with information about proteomics
and informatics is established. At present, there are no concrete epidemiological
data supporting any exogenous EAS contribution to hormone-related organ
carcinogenesis in humans. However, with the establishment of appropriate
animal models and analysis of genomic-scale gene expression, risk identification
and evaluation should be facilitated within a relatively short period,
and this approach eventually promises to contribute a great deal of
risk management regarding EASs.
*Report from a SCOPE/IUPAC project: Implication of
Endocrine Active Substances for Human and Wildlife (J. Miyamoto and
J.Burger, editors). Other reports are published in this issue,
pp. 1617-2615.
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