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Pure Appl. Chem. Vol. 73, No. 10, pp. 1573-1577 (2001)

 

Threading intercalation to double-stranded DNA and the application to DNA sensing. Electrochemical array technique*

Makoto Takagi

Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Higashi, Fukuoka, Japan

Abstract: Electrochemical labeling of double-stranded (ds) DNA is achieved by redox-active DNA intercalators. Threading intercalators derived from naphthalenediimide appended with ferrocene reporter group in the side arms are particularly useful for this purpose. This allows a sensitive electrochemical detection of DNA hybridization on an array, providing a great potential for low-cost, high-throughput, and quick DNA screening technique in post-genome study.

*Lecture presented at the IUPAC International Congress on Analytical Sciences 2001 (ICAS2001), Tokyo, Japan, 6-10 August 2001. Other presentations are published in this issue, pp. 1555-1623.

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