Chemistry and biotransformations in the Scrophulariaceae family*
J. A. Garbarino1,**, B. M. Fraga2, M. G. Hernandez2, M. C. Chamy1,
and M. Piovano1
1Departamento de Química, Universidad Técnica
Federico Santa María, Casilla 110-V, Valparaíso, Chile;
2Instituto de Productos Naturales y Agrobiología, Tenerife, España
Abstract: One of our research lines has been the chemical studies among
Calceolaria species (Scrophulariaceae), from which have been isolated
77 new diterpenes of various skeleton types (labdanes, pimaranes, stemaranes,
and stemodanes), all coming from a common bicyclic intermediate, having
H-9 and C-20 as a cis relationship and C-11 becomes trans with respect
to C-20. Another line of research is bringing out chemical changes on
diterpenes obtained from this family, using biological systems as the
fungus Giberella fujikuroi and Mucor plumbeus.
*Lecture presented at the 22nd IUPAC International
Symposium on the Chemistry of Natural Products, São Carlos, Brazil,
3-8 September 2000. Other presentations are published in this issue,
pp. 549-626.
**Corresponding author
