New nucleoside analogs, synthesis, and biological properties*
M. J. Wanner, P. Y. F. Deghati, B. Rodenko, and G. J. Koomen**
Laboratory of Bioorganic Chemistry, IMC, University
of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands
Abstract: In view of the importance of nucleoside analogs as
enzyme inhibitors and adenosine receptor (ant)agonists, new adenosine
analogs were prepared and their activities studied on adenosine deaminase
in vitro and on A1, A2A, and
A3 receptors. Particularly useful for the synthesis of new
analogs were the applications of the Pd-catalyzed Buchwald reaction
and a radical nitration reaction of purine- and 1-deazapurine nucleosides.
*Lecture presented at the 13th International
Conference on Organic Synthesis (ICOS-13), Warsaw, Poland, 1-5 July
2000.
** Corresponding author
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