Toxicological Evaluation of Certain Veterinary Drug Residues
Prepared by the Fiftieth Meeting of the Joint FAO/WHO Expert Committee
on Food Additives; WHO Food Additives Series, No. 41, 1998, vi + 173
pages (English), ISBN 92 4 166041 4, CHF 50.-/USD 45.00; In developing
countries: CHF 35. Order no. 1270041.
This book evaluates the design and findings of studies relevant
to the safety assessment of selected veterinary drug residues in food.
The book, which is part of a long-running series prepared by the Joint
FAO/WHO Expert Committee on Food Additives (JECFA), gives toxicologists,
the food industry, and regulatory agencies a record of the scientific
evidence considered when the Committee allocates or revises acceptable
daily intakes and other endpoints.
Emphasis is placed on studies that relate specific exposure levels
to specific toxic effects or guide the meaningful extrapolation of
animal data to the human condition. Through its careful attention
to questions of study design, methodology, and the validity of reported
data, the book also demonstrates the strict safety standards used
by JECFA in its efforts to protect consumers from any possible toxicological
or pharmacological hazard linked to the consumption of veterinary
Separate toxicological monographs are presented for four anthelminthic
agents (eprinomectin, febantel fenbendazole, and oxfendazole), three
antimicrobial agents (gentamicin, sarafloxacin, and tetracyclines),
three antiprotozoal agents (diclazuril, imidocarb, and nicarbazin),
one production aid (recombinant bovine somatotropins), and one tranquilizing
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