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IUPAC Prize for Young
Chemists - 2003
Honorable Mention
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Vincent Semetey
receives one of three Honorable Mention awards associated with
the IUPAC Prize for Young Chemists, for his Ph.D. thesis work
entitled "N,N'-linked urea oligomers: synthesis,
conformational studies and self-assembly properties."
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Current address (at the time of application)
Department of Chemistry and Biological Chemistry, Harvard
University, 12 Oxford Street, Cambridge MA 02138, USA
E-mail: [email protected]
Academic degrees
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Ph.D. in Supramolecular Chemistry / Foldamers, Louis
Pasteur University, Strasbourg, France
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MS in Organic Molecular and Supramolecular Chemistry,
Louis Pasteur University, Strasbourg, France
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BS in Chemistry, Louis Pasteur University, Strasbourg,
France
Ph.D. Thesis
Title N,N'-linked urea oligomers:
synthesis, conformational studies and self-assembly properties
Advisers Profs. G. Guichard and J. P. Briand
Thesis Committee Maurice Goeldner, Laboratoire de Chimie Bioorganique,
Louis Pasteur University, Strasbourg, France; Ivan Huc, Laboratoire
de Chimie Supramoleculaire, European Institute for Chemistry and Biology,
Bordeaux, France; Gérard Chassaing, Laboratoire de Chimie Structurale
organique et biologique, Pierre and Marie Curie University, Paris,
France; Andre Aubry, Laboratoire de Cristallographie et Modelisation
des Materiaux Mineraux et Biologiques, Henri Poincarre University,
Nancy, France.
Essay
The functional diversity in proteins, although mediated
by sophisticated tertiary and quaternary structures, relies on a small
set of distinct secondary structural elements: sheets, helices and
turns. Search for new nonnatural oligomers ("foldamers")
designed to reproduce or mimic the essential protein features have
gained considerable interest with potential application in pharmaceutical
research. Seminal works published by the groups of Seebach, Gellman
and Hanessian have revealed that short peptides made exclusively with
enantiopure b- or g-amino
acids, correctly substituted, could form stable helical or pleated-sheet-type
structures in solution and in the solid state.
Full text [pdf file - 694KB]
Page last modified 29 April 2003.
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