Title: Analogue-based drug discovery
Chairman: J. Fischer
Members: E. Breuer,
C.R. Ganellin, G.
Gaviraghi, P. Lindberg,
U. Petersen, J.
Wermuth, and R.
Completion Date: 2005 - project completed
To publish a book on "Analogue-based Drug Discovery".
It should serve as a reference book for medicinal chemists, and afford
an easily usable overview on drugs, drug classification and analogue
The book will illustrate the considerable success that has been
achieved in the development of new drugs based on the leads provided
by established drugs. Such new drugs are often considered deprecatingly
as "me-too" products. However, the book will demonstrate
that it is part of the very important process whereby drug action
is optimized for a given therapeutic effect.
J. Fischer and A. Gere have published the journal article: Pharmazie,
56, 675-682 (2001) on "Timing of analogue research in medicinal
chemistry" in order to initiate a book consisting of the following
One of the task group member (J.P.) has recently published an article
on "Drugs, Leads, and Drug-Likeness" in Bioorganic and Medicinal
Chemistry Letters12, 1647-1650 (2002), which will be developed into
a chapter of the book.
2. Analogue Types in Medicinal Chemistry
The Task Group Chairman (J.F.) will continue the above journal article
in order to obtain an actual and a more comprehensive overview as
a chapter in the book.In this part of the book some examples of successful
analogue discoveries will be described by some of the task group members.
3. Drug Classification
J.F. and his present coworkers describe the most important drugs (around
1 000) in tables classified according to their chemical analogy and
biological action. A group contains chemical analogues with the same
therapeutic area and mechanism of action. The drugs will be ordered
according to their patent priority inside a group. The tables will
offer important informations on the drugs (main therapeutic areas,
mechanism of action, CAS, MW, basic patent, launch, market value).
Book published by Wiley-VCH, Weinheim
2006, ISBN 3-527-31257-9
> see book
Last Update: 12 September 2006
announcement published in Chem.