Organizations & People
Pure Appl. Chem.,
Vol. 71, No. 2, pp.337-348, 1999
INTERDIVISIONAL WORKING PARTY FOR HARMONIZATION OF QUALITY
ASSURANCE SCHEMES FOR ANALYTICAL LABORATORIES*
Harmonized guidelines for the use of
recovery information in analytical measurement
Resulting from the Symposium on Harmonization of Quality
Assurance Systems for Analytical Laboratories, Orlando, USA, 4-5 September
1996 held under the sponsorship of IUPAC, ISO and AOAC INTERNATIONAL
Thompson, Steven L R Ellison, Ales Fajgelj, Paul Willetts and Roger
Synopsis: ISO, IUPAC and AOAC INTERNATIONAL have co-operated
to produce agreed protocols or guidelines on the "Design, Conduct and
Interpretation of Method Performance Studies" 
on the "Proficiency Testing of (Chemical) Analytical Laboratories" 
and on "Internal Quality Control in Analytical Chemistry Laboratories"
. The Working Group that produced these
protocols/guidelines was asked to prepare guidelines on the use of recovery
information in analytical measurement. Such guidelines would have to
outline minimum recommendations to laboratories producing analytical
data on the internal quality control procedures to be employed.
A draft of the guidelines was discussed at the Seventh
International Symposium on the Harmonization of Quality Assurance Systems
in Chemical Laboratory, sponsored by IUPAC/ISO/AOAC INTERNATIONAL, held
in Orlando, USA, 4-5 September 1996. Proceedings from that Symposium
are available .
The purpose of these guidelines is to outline the conceptual
framework needed for considering those types of analysis where loss
of analyte during the analytical procedure is inevitable. Certain questions
cannot be satisfactorily addressed, and hence remain irreducibly complex,
unless such a conceptual framework is established. The questions at
issue involve (a) the validity of methods for estimating the recovery
of the analyte from the matrix of the test material, and (b) whether
the recovery estimate should be used to correct the raw data to produce
the test result. The types of chemical analysis most affected by these
considerations are those where an organic analyte is present at very
low concentrations in a complex matrix.
- "Protocol for the Design, Conduct and Interpretation
of Method Performance Studies", W. Horwitz, Pure Appl. Chem.
60, 855- 864 (1988), revised, 67, 331-343 (1995).
- "The International Harmonized Protocol for the Proficiency
Testing of (Chemical) Analytical Laboratories", M. Thompson and R.
Wood, Pure Appl. Chem. 65, 2123-2144 (1993). (Also published
in J. AOAC International 76, 926-940 (1993).
- "Harmonized Guidelines for Internal Quality Control
in Analytical Chemistry Laboratories", M. Thompson and R. Wood, Pure
Appl. Chem. 67, 49-56 (1995).
Assurance for Analytical Laboratories", edited M. Parkany, Royal
Society of Chemistry, London, UK, 1996.
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