29 No. 5
Biomineralization—Medical Aspects of Solubility
edited by Erich Königsberger and LanChi Königsberger
John Wiley & Sons, 2006
Solubility phenomena are fundamental to living organisms and range from gas solubilities (e.g., oxygen in blood) to biomineral formation in body fluids. This book comprises five chapters that offer various perspectives on normal and pathological biomineralization in humans.
- Chapter 1 (Erich Königsberger and LanChi Königsberger) gives an overview of experimental and modeling methods, recommends solubility data for selected stone-forming substances, and describes recently discovered, unusual dissolution and crystallization phenomena involving nano-sized biomaterials.
- Chapter 2 (Félix Grases and Antonia Costa-Bauzá) presents a general classification of renal and salivary calculi based on their formation mechanism.
- Chapter 3 (M. Clara F. Magalhães, Paula A.A.P. Marques, and R.N. Correia) reviews the solubilities of calcium and magnesium phosphates and discusses their relevance to normal and pathological mineralization in terms of stability field diagrams.
- Chapter 4 (Fairland F. Amos, Matthew J. Olszta, Saeed R. Khan, and Laurie B. Gower) proposes a new paradigm for biomineralization—liquid phase precursors—and their possible roles in the formation of bone and kidney stones.
- In Chapter 5 (Wanida Chua-anusorn and Timothy G. St Pierre), various aspects of the biomineralization of iron and its relation to iron overload diseases are discussed.
Aimed at chemists interested in solution chemistry, thermodynamics, kinetics, crystallization, biochemistry, biomineralization, and medicinal chemistry, this book is also relevant to doctors and biologists interested in research in urology, nephrology, clinical chemistry, and chelation therapy.
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