Chemistry International
Vol. 21, No. 5
September 1999
Medicinal
Chemistry Graduate School Curriculum and Its Contribution to the Pharmaceutical
Industry in Japan
Survey Outcome and Analysis
Q 1: How many postgraduate students
and postdoctorals are currently enrolled for studies considered primarily
involving medicinal chemistry?
Q 2: What is the total number of
postgraduates (M.Sc. and Ph.D.) irrespective of medicinal chemistry?
Q 3: What is the B.Sc. specialization
of the graduate students?
Q 4: How many M.Sc./Ph.D. graduates
have, in the last 5 years, had their primary focus on medicinal chemistry,
and what is their present occupation?
Q 5: How many of the above postdocs
have Ph.D. degrees in organic chemistry?
Q 6: Do you have short courses
on aspects of drug design available to medicinal chemists in the pharmaceutical
industry?
Q 7: How many academic staff are
engaged in the education of M.Sc. and Ph.D. students, and how many academic
staff from outside are involved?
Q 8: Do your Ph.D. students attend
lecture courses?
Q 9: Do your Ph.D. students have
to develop their presentation skills?
Q 1:
How many postgraduate students and postdoctorals are currently enrolled
for studies considered primarily involving medicinal chemistry?
Answer
|
Type 1
|
Type 2
|
Type 3
|
Number of Replies |
3
|
3
|
7
|
M.Sc. |
182
|
192
|
198
|
Ph.D. |
86
|
24
|
28
|
Subtotal |
268
|
216
|
226
|
Postdoctoral |
11
|
0?
|
13
|
Total |
279
|
216
|
239
|
Average Number per Graduate School
|
93
|
72
|
34
|
*Virtual Total |
93x6
|
72x11
|
34x29
|
Number |
558
|
792
|
986
|
Virtual Grand Total |
|
>2 000
|
|
*Virtual Total means an estimated
total number of all graduate students and postdoctorals.
Example:
Type 3: Average (34) x total schools (29) = 986
Finding 1: More than 2 000 postgraduate students (M.Sc. and
Ph.D.) in Pharmaceutical Sciences are involved in Medicinal Chemistry
Research or Medicinal Innovations annually in Academia.
Q 2: What
is the total number of postgraduates (M.Sc. and Ph.D.) irrespective of
medicinal chemistry?
Answer
|
Type 1
|
Type 2
|
Type 3
|
Number of Replies |
3
|
3
|
7
|
M.Sc. + Ph.D |
280
|
107
|
65
|
|
|
|
120
|
|
150
|
149
|
52
|
|
164
|
200
|
80
|
|
|
|
36
|
|
|
|
40
|
|
|
|
50
|
Total |
594
|
456
|
425
|
Average per School |
198
|
152
|
61
|
*Virtual Total |
198x6
|
152x11
|
61x29
|
|
1 118
|
1 672
|
1 769
|
Virtual Grand Total |
about 4 500
|
*Virtual Total means an estimated
total number of graduate students of total graduate schools (6 + 11
+ 29 = 46)
Example:
Type 1: Average (198) of the replies (3) x graduate
schools (6) = 1 188
Finding 2: Referring to Finding 1, about 45% of the total
postgraduates in Pharmaceutical Sciences are involved in Medicinal
Chemistry or Medicinal Innovation in academia.
Q 3:
What is the B.Sc. specialization of the graduate students?
Answer
|
Type 1
|
Type 2
|
Type 3
|
Number of Replies |
3
|
3
|
7
|
B. Pharmaceutical Sciences
|
259
|
208
|
211
|
Other B. Sc |
3
|
0?
|
13
|
B. Sc Other Countries |
6
|
8
|
2
|
|
268
|
216
|
226
|
Finding 3: Almost 95% of graduate students have an educational
background in the pharmaceutical sciences. The graduate school is
not diversified in terms of B. Sc. background; rather, the undergratuate
training of the students is very homogeneous. However, this finding
might reflect a well-diversified faculty education in almost all natural
sciences.
Q 4: How
many M.Sc./Ph.D. graduates have, in the last 5 years, had their primary
focus on medicinal chemistry, and what is their present occupation?
Answer
|
Type 1
|
Type 2
|
Type 3
|
Number of Replies |
3
|
3
|
7
|
|
MSc/PhD
|
MSc/PhD
|
MSc/PhD
|
Total Number Graduated |
535
|
435
|
340
|
Virtual Number Graduated
|
535x1/3x6
1 069
|
435x1/3x11
1 595
|
340x1/6x29
1 643
|
Postdoc Research (Home) |
11
|
0
|
2
|
Postdoc Research (Abroad) |
13
|
2
|
3
|
Academic/Teaching Position
|
16
|
4
|
15
|
Drug Analysis |
18
|
20
|
0
|
DMPK |
52
|
34
|
5
|
Patents or Information |
11
|
0
|
3
|
Synthetic Med Chem |
65
|
54
|
28
|
Computer-Assisted Drug Design |
31
|
3
|
3
|
Drug Registration orClinical Research
|
18
|
28
|
0
|
Marketing |
4
|
0
|
10
|
Sales Representatives |
2
|
0
|
15
|
Other |
0
|
5
|
34
|
Unknown |
9
|
4
|
25
|
Number Going to Industry |
358
|
318
|
241
|
% Going to Industry |
67%
|
73%
|
71%
|
|
(358/535)
|
(318/435)
|
(241/340)
|
*Virtual Number to Industry
|
358x1/3x6
|
318x1/3x11
|
241x1/6x29
|
|
716
|
1 166
|
1 165
|
Virtual Grand Total |
about 3 000
|
*Virtual Number means an estimated number of total
graduate schools.
Example:
Type 2: Average (1 318 x 1/3) x number of graduate
schools (11) = 1 166
Finding 4: Benchmarking M.Sc./Ph.D. graduates from the last
5 years and their current jobs is so difficult and complex that it
might be dangerous to comment in detail on the outcomes; however,
about 70% joined industry. It is also a new phenomenon for M.Sc./Ph.D.
graduates to begin their careers in the development and commercialization
aspects of medicinal innovation, such as clinical research and drug
registration as well as marketing and sales.
Q 5: How many of the above postdocs
have Ph.D. degrees in organic chemistry?
This question is not self-explanatory in terms of
Organic Chemistry in the faculties of Pharmaceutical Sciences, Sciences,
Agricultural Sciences, or Technology. While some reengineering is proceeding
in the university system, almost all universities in Japan still have
the faculty system.
Finding 5: No clear database was obtained.
Q 6: Do you have short courses
on aspects of drug design available to medicinal chemists in the pharmaceutical
industry?
Answer
|
Type 1
|
Type 2
|
Type 3
|
Number of Replies |
3
|
3
|
7
|
Yes |
2
|
2
|
2
|
Finding 6: The "Yes" responses do not imply that
the schools have official courses available to industry. It seems
reasonable to infer that through symposia, seminars, and scientific
meetings, there are opportunities for academia to provide advice on
drug design.
Q 7: How many academic staff
are engaged in the education of M.Sc. and Ph.D. students, and how many
academic staff from outside are involved?
Answer
|
Type 1
|
Type 2
|
Type 3
|
(Graduate School)
|
(Faculty)
|
(Faculty)
|
Number of Replies |
3
|
3
|
7
|
Academic Staff Internal* |
93
|
57
|
63
|
|
55
|
59
|
104
|
|
57
|
48
|
69
|
|
|
|
66
|
|
|
|
65
|
|
|
|
60
|
|
|
|
71
|
Subtotal |
205
|
164
|
498
|
Average per School |
68
|
55
|
71
|
Virtual Total Staff |
68 x 6
|
55 x 11
|
71x29
|
|
408
|
605
|
2 059
|
Virtual Grand Total
|
about 3 000
|
*Reasonable and
meaningful database on external numbers not obtained this time.
Finding 7: Frankly, this question was controversial in terms
of numbers involved in medicinal chemistry, because it is almost impossible
to estimate all individual staff percentages engaged in medicinal
chemistry; therefore, the data obtained indicate a total number of
academic staff in graduate school and faculty of Pharmaceutical Sciences.
It should be noted that these staff are also deeply involved in teaching
undergraduates, who total around 8 000/year in Japan. The Japanese
undergraduate curriculum (4 years) comprises General Study (less than
1.5 years) and Pharmaceutical Sciences (more than 2.5 years), so that
a total number of undergraduates of Pharmaceutical Sciences would
be more than 30 000 in Japan. One academic staff member per 10_11
undergraduate students would be considered quite high compared with
the ratio for other faculties.
Q 8: Do your Ph.D. students
attend lecture courses?
Answer
|
Type 1
|
Type 2
|
Type 3
|
Number of Replies |
3
|
3
|
7
|
Yes |
1
|
3
|
4
|
Finding 8: Attendance at lecture courses depends on school
policy.
Q 9: Do your Ph.D. students
have to develop their presentation skills?
Answer
|
Types 1, 2, and 3
|
Total Number of Replies |
|
13
|
Present a Seminar
|
|
13
|
Write a Report (apart from Thesis) |
|
13
|
Present a Communication at a Scientific Conference
|
|
13
|
Finding 9: Research quality and productivity are appraised
not only internally but also externally, and communication is essential.
All schools are cognizant of fostering the skills of Ph.D. students
in communication as well as in research itself.