Chemistry International
Vol. 21, No.5, September 1999

1999, Vol. 21
No. 5 (September)
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.. New Projects
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Chemistry International
Vol. 21, No. 5
September 1999

Medicinal Chemistry Graduate School Curriculum and Its Contribution to the Pharmaceutical Industry in Japan

Survey Outcome and Analysis

Q 1: How many postgraduate students and postdoctorals are currently enrolled for studies considered primarily involving medicinal chemistry?

Q 2: What is the total number of postgraduates (M.Sc. and Ph.D.) irrespective of medicinal chemistry?

Q 3: What is the B.Sc. specialization of the graduate students?

Q 4: How many M.Sc./Ph.D. graduates have, in the last 5 years, had their primary focus on medicinal chemistry, and what is their present occupation?

Q 5: How many of the above postdocs have Ph.D. degrees in organic chemistry?

Q 6: Do you have short courses on aspects of drug design available to medicinal chemists in the pharmaceutical industry?

Q 7: How many academic staff are engaged in the education of M.Sc. and Ph.D. students, and how many academic staff from outside are involved?

Q 8: Do your Ph.D. students attend lecture courses?

Q 9: Do your Ph.D. students have to develop their presentation skills?


 

Q 1: How many postgraduate students and postdoctorals are currently enrolled for studies considered primarily involving medicinal chemistry?

Answer

 
Type 1
Type 2
Type 3
Number of Replies
3
3
7
M.Sc.
182
192
198
Ph.D.
86
24
28
Subtotal
268
216
226
Postdoctoral
11
0?
13
Total
279
216
239

Average Number per Graduate School

93
72
34
*Virtual Total
93x6
72x11
34x29
Number
558
792
986
Virtual Grand Total  
>2 000
 

*Virtual Total means an estimated total number of all graduate students and postdoctorals.

Example:

Type 3: Average (34) x total schools (29) = 986

Finding 1: More than 2 000 postgraduate students (M.Sc. and Ph.D.) in Pharmaceutical Sciences are involved in Medicinal Chemistry Research or Medicinal Innovations annually in Academia.


Q 2: What is the total number of postgraduates (M.Sc. and Ph.D.) irrespective of medicinal chemistry?

Answer

 
Type 1
Type 2
Type 3
Number of Replies
3
3
7
M.Sc. + Ph.D
280
107
65
     
120
 
150
149
52
 
164
200
80
     
36

 

   
40
     
50
Total
594
456
425
Average per School
198
152
61
*Virtual Total
198x6
152x11
61x29
 
1 118
1 672
1 769
Virtual Grand Total
about 4 500

*Virtual Total means an estimated total number of graduate students of total graduate schools (6 + 11 + 29 = 46)

Example:

Type 1: Average (198) of the replies (3) x graduate schools (6) = 1 188

Finding 2: Referring to Finding 1, about 45% of the total postgraduates in Pharmaceutical Sciences are involved in Medicinal Chemistry or Medicinal Innovation in academia.


Q 3: What is the B.Sc. specialization of the graduate students?

Answer

 
Type 1
Type 2
Type 3
Number of Replies
3
3
7

B. Pharmaceutical Sciences

259
208
211
Other B. Sc
3
0?
13
B. Sc Other Countries
6
8
2
 
268
216
226

Finding 3: Almost 95% of graduate students have an educational background in the pharmaceutical sciences. The graduate school is not diversified in terms of B. Sc. background; rather, the undergratuate training of the students is very homogeneous. However, this finding might reflect a well-diversified faculty education in almost all natural sciences.


Q 4: How many M.Sc./Ph.D. graduates have, in the last 5 years, had their primary focus on medicinal chemistry, and what is their present occupation?

Answer

 
Type 1
Type 2
Type 3
Number of Replies
3
3
7
 
MSc/PhD
MSc/PhD
MSc/PhD
Total Number Graduated
535
435
340

Virtual Number Graduated

535x1/3x6
1 069
435x1/3x11
1 595
340x1/6x29
1 643
Postdoc Research (Home)
11
0
2
Postdoc Research (Abroad)
13
2
3

Academic/Teaching Position

16
4
15
Drug Analysis
18
20
0
DMPK
52
34
5
Patents or Information
11
0
3
Synthetic Med Chem
65
54
28
Computer-Assisted Drug Design
31
3
3

Drug Registration orClinical Research

18
28
0
Marketing
4
0
10
Sales Representatives
2
0
15
Other
0
5
34
Unknown
9
4
25
Number Going to Industry
358
318
241
% Going to Industry
67%
73%
71%
 
(358/535)
(318/435)
(241/340)

*Virtual Number to Industry

358x1/3x6
318x1/3x11
241x1/6x29
 
716
1 166
1 165
Virtual Grand Total
about 3 000

*Virtual Number means an estimated number of total graduate schools.

Example:

Type 2: Average (1 318 x 1/3) x number of graduate schools (11) = 1 166

Finding 4: Benchmarking M.Sc./Ph.D. graduates from the last 5 years and their current jobs is so difficult and complex that it might be dangerous to comment in detail on the outcomes; however, about 70% joined industry. It is also a new phenomenon for M.Sc./Ph.D. graduates to begin their careers in the development and commercialization aspects of medicinal innovation, such as clinical research and drug registration as well as marketing and sales.


Q 5: How many of the above postdocs have Ph.D. degrees in organic chemistry?

This question is not self-explanatory in terms of Organic Chemistry in the faculties of Pharmaceutical Sciences, Sciences, Agricultural Sciences, or Technology. While some reengineering is proceeding in the university system, almost all universities in Japan still have the faculty system.

Finding 5: No clear database was obtained.


Q 6: Do you have short courses on aspects of drug design available to medicinal chemists in the pharmaceutical industry?

Answer

 
Type 1
Type 2
Type 3
Number of Replies
3
3
7
Yes
2
2
2

Finding 6: The "Yes" responses do not imply that the schools have official courses available to industry. It seems reasonable to infer that through symposia, seminars, and scientific meetings, there are opportunities for academia to provide advice on drug design.


Q 7: How many academic staff are engaged in the education of M.Sc. and Ph.D. students, and how many academic staff from outside are involved?

Answer

 
Type 1
Type 2
Type 3
(Graduate School)
(Faculty)
(Faculty)
Number of Replies
3
3
7
Academic Staff Internal*
93
57
63

 

55
59
104
 
57
48
69
     
66

 

   
65
     
60
     
71
Subtotal
205
164
498
Average per School
68
55
71
Virtual Total Staff
68 x 6
55 x 11
71x29
 
408
605
2 059

Virtual Grand Total

about 3 000

*Reasonable and meaningful database on external numbers not obtained this time.

Finding 7: Frankly, this question was controversial in terms of numbers involved in medicinal chemistry, because it is almost impossible to estimate all individual staff percentages engaged in medicinal chemistry; therefore, the data obtained indicate a total number of academic staff in graduate school and faculty of Pharmaceutical Sciences. It should be noted that these staff are also deeply involved in teaching undergraduates, who total around 8 000/year in Japan. The Japanese undergraduate curriculum (4 years) comprises General Study (less than 1.5 years) and Pharmaceutical Sciences (more than 2.5 years), so that a total number of undergraduates of Pharmaceutical Sciences would be more than 30 000 in Japan. One academic staff member per 10_11 undergraduate students would be considered quite high compared with the ratio for other faculties.


Q 8: Do your Ph.D. students attend lecture courses?

Answer

 
Type 1
Type 2
Type 3
Number of Replies
3
3
7
Yes
1
3
4

 

Finding 8: Attendance at lecture courses depends on school policy.


Q 9: Do your Ph.D. students have to develop their presentation skills?

Answer

 
Types 1, 2, and 3
Total Number of Replies  
13

Present a Seminar

 
13
Write a Report (apart from Thesis)  
13

Present a Communication at a Scientific Conference

 
13

Finding 9: Research quality and productivity are appraised not only internally but also externally, and communication is essential. All schools are cognizant of fostering the skills of Ph.D. students in communication as well as in research itself.

 

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