S.S. Brown, F.W. Sunderman
Blackwell Science, 1985 [ISBN 0632013559]
The Third International Conference on Nickel
Metabolism and Toxicology was held at the PLM St Jacques Hotel in Paris
in September 1984, under the joint sponsorship of the International
Union of Pure and Applied Chemistry (IUPAC), the Association of Clinical
Scientists, and the Nickel Producers Environmental Research Association
(NiPERA). The Paris Conference was attended by 150 participants from
19 countries, including many of the world's authorities on nickel in
the areas of trace analysis, biochemistry, radiochemistry, pharmacology,
toxicology, pathology, immunology, industrial hygiene, epidemiology,
occupational health and clinical medicine. The text of the Richard T.
Barton memorial lecture and synopses of the scientific papers that were
presented at the Conference are published in this volume, which provides
a valuable reference for postgraduate and research workers in toxicology,
clinical chemistry and pathology.
Contents
Introduction: 100 years of nickel toxicology;
Muscle tumorigenesis by nickel compounds Carcinogenesis; In vitro study
of Ni3S2-induced rhabdomyosarcomas in normal and polymyopathic hamsters;
Effects of calcium and megnesium salts on nickel subsulfide carcinogenesis
in Fischer rats; Nickel-induced malignant tumors; Tumor induction in
rats after intrapleural injection of nickel subsulphide and nickel oxide;
Electron microscopy of pulmonary lesions, including carcinoma, induced
by inhalation exposure of rats to nickel oxide aerosol; Electron microscopic
observations on leiomyosarcomas induced with nickel subsulfide; Toxicology
and carcinogenesis studies of nickel oxide, nickel sulfate and nickel
subsulfide: design od study and characterization of nickel compounds;
Alterations of human fetal kidney epithelial cells produced by nickel
sulfate; Biological characterization of cells cultured from a sinonasal
carcinoma of a former nickel worker; Incorporation of Ni3S2 and NiS
into human embryonic pulmonary cells in culture; Toxicology X-ray microanalytical
and autoradiographic detection of nickel in bacterial cells; Solubility
of metallic nickel and nickel oxides in a biological fluid at different
pH levels; An in vitro genotoxicity assay to complement in vivo inhalation
studies and for occupational monitoring of metallic aerosols and welding
fumes; Pulmonary deposition and clearance of inhaled nickel oxide aerosol;
Comparative toxicity of nickel salts to the lung; Alveolar proteinosis
induced in rats by long-term inhalation of nickel oxide Increased lipid
peroxidationin liver, kidney and lung of NiCl2-treated rats; Effects
of unilateral administration of nickel subsulfide to rats on erythropoietin
concentrations in serum and in extracts of both kidneys; Further insights
into mehanisms of nickel-induced DNA damage: studies with cultured rat
liver cells; Relationships between nickel ingestion and calcium, magnesium
and glucose in the rat; Critical review of the evidence for nickel(III)
in animals and man; Left-handed structures of alternating purine-pyramidine
polynucleotides induced by Ni2+ ions: an I R spectroscopy study; Activation
of the calmodulin-dependent phosphoprotein phosphatase by nickel ions;
Clinical pathology; Simultaneous determination of nickel and cadmium
in whole blood by Zeeman atomic absorption spectrophotometry: blood
nickel and cadmium levels in the general population of Denmark; Square
wave voltammetry: a new approach for the sensitive determination of
nickel and cobalt in human samples; Hypernickelemia in hemodialysis
patients; Serum and lymphocyte nickel and aluminium concentrations in
patients with extracorporeal hemodialysis; The measurement of nickel
in chronic renal failure; Serum nickel concentrations in patients with
unstable angina pectoris and acute myocardial infarction; Urinary excretion
of nickel and chrmium in workers of a steel foundry; External and internal
nickel exposure of arc welders during one working week; Effects of NiCl2
and diethyldithiocarbamate on heme oxygenase, metallothionein, glutathione
and trace metals in rat liver and kidney; The effect of nickel and manganese
on natural killer cell activity; Nickel-induced occupational asthma:
immunological and clinical aspects; Biological consequences of long-term
exposure to orthopaedic implants; Cytology as a screening method in
the detection of precancerous nasal mucosal changes in nickel workers;
Occupational Exposures; Atmospheric monitoring of nickel-containing
dusts at the INCO refinery in Clydach, Wales; The determination of occupational
exposure to airborne dust containing nickel; NiPERA 82-06 air sampling
method for inorganic nickel; Concentration du nickel et du chrome dans
l'atmosphere des ateliers siderurgiques; Un nouvel appareil de prelevement
de poussieres, le CI P10; Estimating past exposures to airborne nickel
compounds in the Copper Cliff sinter plant; Mortality analysis in a
Canadian sinter plant: a comparison of two cohorts based on year of
first hiring; Incidence des cancers respiratoires chez les travailleurs
d'une entreprise d'extraction et de raffinage du nickel et dans la population
generale en Nouvelle-Caledonie; respiratoires parmi les travailleurs
d'une entreprise d'extraction et de raffinage du nickel en Nouvelle-Caledonie:
une etude cas-termoins au Sein d'une cohorte; Toxicological and occupational
medical investigations concerning nickel exposure in different industrial
areas in the FRG; Health surveillance of SLN workers; Health surveillance
of workers exposed to nickel and its compounds; Study of nickel-bearing
dusts and biological implants by microdifferentially thermal analysis;
Generation of various types of nickel-containing aerosols and detection
of nickel species in these aerosols; Nickel oxide and nickel subsulfide
resulting from attack of super alloys in aeronautical gas turbines by
fuel combustion products
67 illustrations
270 pages