Title: Recommendations for nomenclature and
databases for biochemical thermodynamics
Dixon, Robert N.
Goldberg, Gordon Hammes,
Keith Tipton, and
Hans V. Westerhoff
To revise IUPAC Recommendations for Nomenclature and Tables in Biochemical
Thermodynamics 1994*. Update these recommendations and increase their
usefulness by providing more about computers and databases that have
been developed since 1994. Describe the connection between the thermodynamics
of enzyme-catalyzed reactions and the kinetics of enzyme-catalyzed
reactions that is provided by Haldane relations.
*Pure Appl. Chem. 66, 1641-1666 (1994) >
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The concept of a transformed Gibbs energy G' that provides the
criterion for spontaneous change and equilibrium at a specified pH
was developed in 1992 (Alberty, Biophys. 42, 117-131 and 43,
239-254), and so it is quite remarkable that the IUPAC Recommendations
were published in Pure Appl. Chem. 66, 1641-1666 (1994). They
were reprinted in Eur. J. Biochem. 240, 1-14 (1996).
A lot has happened in the field since 1994, especially
the use of computers and the publication of articles and putting databases
on the web. A book titled 'Biochemical
Thermodynamics: Applications of Mathematica (Wiley, Hoboken, NJ
(2006), ISBN: 0-471-75798-5) that gives apparent equilibrium constants
at 298.15 K, 0.25 M ionic strength, and pHs 5 to 9 for over 300 enzyme-catalyzed
reactions was written by the Task Group Chair.
These Recommendations are to be published as IUPAC-IUBMB
Joint Commission on Biochemical Nomenclature (JCBN).
The Sections to be drafted include: