Number: 2002-038-1-500
Title: Solubility data of compounds relevant to human health.
Antibiotics: peptide antibiotics and macrocyclic lactone antibiotics
Series: Solubility Data Series; editor-in-chief: Mark
Salomon
Task Group Chairman: J.W.
Lorimer
Objective/Description:
The solubilities of antibiotics are of major importance in pharmaceutical
and medicinal chemistry. For example, drug delivery formulations which
directly relate to anti-bacterial activities depend strongly on solubility.
The search for new antibiotics resistant to continually evolving bacterial
strains is a major focus of drug R&D worldwide, and here solubilities
are important in helping the design processes. The compilation and,
where possible, critical evaluation of solubilities for these compounds
can be expected to play a major role in the design and delivery of chemotherapeutic
drugs now undergoing extensive R&D.
Compilations are available already for many peptide and macrocyclic
lactone antibiotics, with literature surveyed up to about 1985. The
compilations need to be extended to cover more modern work and other
antibiotics belonging to these two classes. Task group members with
this expertise are being recruited.
In this project, solubilities of two classes of antibiotics in both
aqueous and non-aqueous solvents are compiled, and critical evaluations
are made in the few cases where sufficient reliable data are available.
The two classes are peptide antibiotics (such as actinomycin) and macrocyclic
lactone antibiotics (such as erythromycin).
Progress:
To be published as part of the IUPAC-NIST Solubility Data Series.
in J. Phys. Chem. Ref. Data.
Project postponed
Last Update: 24 October 2005
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