Number: 2001-055-1-500 (former 560/41/97)
Title: Critical evaluation of stability constants of metal complexes
of complexones for biomedical and environmental applications
Task Group
Chariman: K. Popov
Members:
G. Anderegg, F.
Arnaud-Neu, R. Delgado,
and J. Felcman
Completion Date: 2005 - Project completed
Objective:
Critical review of stability constants concerning the complexation
of all cations by complexones in aqueous solutions with an emphasis
on physiological conditions (35-36 C, 0.15 M NaCl)
Description:
Complexones are synthetic aminoacids Containing more than one carboxy
group. They are widely used in a broad variety of medical, industrial
and environmental applications. Two representatives (NTA, EDTA) have
already been examined by IUPAC (Prof. G.Anderegg). There is strong need
for a critical review of stability constants and thermodynamic functions
of their closest analogues, especially macrocyclic ones. Currently,
even data compilations are missing, and divergent data have not yet
been reconciled. In view of the very large number of references, critical
evaluations have to be restricted to 7 compounds with density ranging
from 3 to 10. We have selected the most studied common chelators: IDA,
MIDA, DTPA, TTHA, DOTA, NOTA and TETA.
Progress:
(Nov 2004) The first draft has been reviewed by the Division and is
now being revised for consideration by the ICTNS.
Project completed - IUPAC Technical Report published in Pure
Appl. Chem.
77(8), 1445-1495, 2005
Last update: 30 August 2005
