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Current Project

Chemistry and Human Health Division (VII)


Number: 2000-009-1-700

Title: Metabolism terms

Task Group
Paul W. Erhardt

Members: Ken Bachmann, Don Birkett, Mike Boberg, Nick Bodor, Gordon Gibson (Editor Xenobiotica), Dave Hawkins (Editor Biotransformations), Gabrielle Hawksworth (Chairperson Drug Metab. Sect. IUPHAR), Jack Hinson (Editor Drug Metabolism Reviews), Hiroshi Masumoto, Ray Novak (Editor Drug Metabolism & Disposition), Phillip Portoghese (Editor J. Medicinal Chemistry), Teresa Serafini, and Nicolas Vermeulen

To compile a list of terms with their definitions in the area of drug metabolism and to disseminate the list to the scientific community.

About 150 terms directly related to the field of drug metabolism will be compiled and defined by this expert group for dissemination to the scientific community. This will help achieve a common definition base across the various publications in this field. In addition, a more uniform use of these terms should assist in the future construction of databases pertaining to this field's information.

This project was presented at a poster session at the IUPAC Congress/GA July 2001
>view pdf - 316KB<

The working party has pared-down its initial, all-inclusive list of over 600 terms related to drug metabolism, to a focused list of about 170 terms. The latter better represents just those terms that are the most relevant for medicinal chemistry. To generate definitions, the shortened list has been divided evenly among the 15 experts who are participating on this task group (ca. 11 terms each). About one-third of the terms now have draft definitions. When the latter are complete, they will be reviewed by the entire working party for finalization. It is anticipated that this project will be completed before the end of 2002. Several of the task group's experts hold editorial positions on major journals associated with medicinal chemistry and drug metabolism, and they would also like to publish the terms (after the terms' appearance in PAC).

(May 2007) All terms have been defined and while most are also finalized among the Working Party, several are undergoing minor revision. At the same time, the overall formatting is being adjusted to the latest ICTNS requirements. It is now anticipated that these terms will be ready for publication by 2008.

Last Update: 8 May 2007

<project announcement published in Chem. Int. 23(3) 2001>


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