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Project

Analytical Chemistry Division (V)

COMMISSION ON SPECTROCHEMICAL AND OTHER OPTICAL PROCEDURES FOR ANALYSIS (V.4)

Number: 540/25/98

Title: Critical Assessment of Spectrochemical Methods in High-Throughput Screening and Combinatorial Technologies

Coordinator(s): G. Gauglitz

Completion Date: 2000

Objective:
Modern approaches in drug design, combinatorial chemistry, environmental screening, toxicological screening, and genomics analysis require a new generation of analytical techniques and instrumentation offering massively parallel monitoring of large numbers of samples. High-throughput screening is a technology recently developed for real-time applications. Increasing demand for combinatory techniques is urgently needed for a wide variety of applications such as genome analytics, drug screening, gene diagnostics as well as analytics in combinatorial chemistry. In addition there is an urgent need for multi-sample and multi-analyte measurements in environmental analytics. The critical assessment will cover the spectrochemical techniques feasible to high throughput screening of samples in the fields mentioned. The project intends to give an overview on operating principles as well as available instrumentation and will define standards for performance criteria.

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