Number: 753/1/95
Title: Nomenclature Guidelines for Combinatorial
Chemistry in the Synthesis and Screening of Compound Libraries
Coordinator(s): Dr.
D. Maclean - Access
to list of members
Completion Date: 2000 - project terminated
Objective:
Combinatorial Chemistry involving the rapid synthetic assembly of
structural building blocks in various possible combinations to produce
large libraries of compounds for drug screening purposes is a rapidly
expanding field of Medicinal Chemistry. Since these combinatorial
libraries can number in the millions of compounds nomenclature issues
arise as to how the compounds within such libraries should be designated.
The objective of the Working Party is to arrive at a set of recommended
nomenclature guidelines for this purpose.
Progress:
Efforts have been directed into two areas.
Firstly to identify new terminology and usages which
have entered the literature of combinatorial chemistry, and to define
and/or clarify their meaning. This will result in a glossary for
Combinatorial Chemistry which should appear in 1999.
> Technical Report published published in Pure
Appl. Chem.,
71(12), 2349-2365 (1999), entitled 'Glossary of terms used in
combinatorial chemistry'.
Also, it is hoped to arrange the appearance of this
publication in a key journal in this specialty.
Secondly, an effort is underway to provide systematic
methods for the reporting and recording of structures in combinatorial
libraries. It is hoped that this will result in a set of standards
for publication of combinatorial methods which will facilitate indexing
and automated retrieval of work in this field. Recommendations for
this portion of our work are expected in Q41999/Q12000.
Last update: 16 June 2000
Project terminated 31 dec 2001
